Self-Microemulsifying Drug Delivery Systems: Formulation Design and Characterization

American Journal of PharmTech Research

article

Sharvani K¹  Shripathy D¹  A R Shabaraya¹ 

[1] Department of pharmaceutics, Srinivas college of pharmacy Valachil

关键词: Microemulsion;    Self-emulsification;    Surfactants;    Bioavailability;   

DOI  :  10.5281/zenodo.7106684

学科分类：药学

来源: American Journal Of Pharmtech Research

【 摘 要 】

Oral route has been considered as most convenient route but restricted to only hydrophilic compounds having GI stability and greater dissolution. The delivery of lipophilic compounds has been area of interest since most of the drugs under discovery shows limited bioavailability. Selfemulsifying delivery systems (SMEDDS) has drawn a greater attention in the formulation of poorly soluble compounds where increase in the absorption and permeation of the drug has observed. The self-emulsification which occurs in the case of SMEDDS has shown a potential advantage over conventional emulsion due to the fine globules formed upon dilution. The recent trends such as dry emulsion, s-SMEDDS, SNEDDS thoroughly investigated. This article, attempts to present the overview of the SMEDDS along with its formulation, application and characterization.

【 授权许可】

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