The correlation between severe complications and blood group types in COVID-19 patients; with possible role of T polyagglutination in promoting thrombotic tendencies

AIMS Medical Science

article

Gasim Dobie¹  Sarah Abutalib¹  Wafa Sadifi¹  Mada Jahfali¹  Bayan Alghamdi¹  Asmaa Khormi¹  Taibah Alharbi¹  Munyah Zaqan¹  Zahra M Baalous¹  Abdulrahim R Hakami²  Mohammed H Nahari³  Abdullah A Mobarki¹  Muhammad Saboor⁴  Mohammad S Akhter¹  Abdullah Hamadi⁵  Denise E Jackson⁶  Hassan A Hamali¹ 

[1] Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University;Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University;Department of Medical Laboratory Technology, Najran University;College of Health Science, Department of Medical Laboratory science, Sharjah University;Department of Medical Laboratory Technology, College of Applied Medical Sciences, Tabuk University;Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology ,(RMIT) University

关键词: COVID-19;    ABO blood group;    D-dimer;    anti-T;    severity;   

DOI  :  10.3934/medsci.2023001

来源: American Institute of Mathematical Sciences

【 摘 要 】

IntroductionCoronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still posing detrimental effects on people. An association between contracting COVID-19 and the ABO blood group type has been determined. However, factors that determine the severity of COVID-19 are not yet fully understood. Thus, the current study aimed to investigate whether the ABO blood group type has a role in the severity of complications due to COVID-19. Materials and methodsEighty-Six ICU-admitted COVID-19 patients and 80 matched-healthy controls were recruited in the study from Baish general hospital, Saudi Arabia. ABO blood grouping, complete blood count (CBC), CBC-derived inflammatory markers, coagulation profile, D-Dimer and anti-T antigen were reported. ResultsOur data showed that patients with blood groups O and B are more protective against severe complications from COVID-19, as compared to patients with blood groups A and AB. This could be partially attributed to the presence of anti-T in blood group A individuals, compared to non-blood group A. ConclusionThe current study reports an association between the ABO blood group and the susceptibility to severe complications from COVID-19, with a possible role of anti-T in driving the mechanism of the thrombotic tendency, as it was also correlated with an elevation in D-dimer levels.

【 授权许可】

CC BY