SARS-CoV-2 Infection and Microbiota Alterations; Potential Beneficial Roles of Probiotics: A Review Article

International Journal of Enteric Pathogens

article

Reza Kargar¹  Aylar Erfanian²  Solat Eslami³  Mohammad Akhoondian⁴  Ali Taherinia⁵  Shahrooz Yazdani⁶ 

[1] School of Medicine, Alborz University of Medical Sciences;School of Allied Medical Sciences, Alborz University of Medical Sciences;Dietary Supplements & Probiotic Research Center, Alborz University of Medical Sciences;Department of Physiology, School of Medicine, Guilan University of Medical Sciences;Department of Emergency Medicine, Alborz University of Medical Sciences;Cardiovascular Research Center, Alborz University of Medical Sciences

关键词: SARS-CoV-2;    Microbiota;    Probiotic;    Dysbiosis;    Immune system;   

DOI  :  10.34172/ijep.2021.30

学科分类：农业科学（综合）

来源: Alborz University of Medical Sciences

【 摘 要 】

The coronavirus disease 2019 (COVID-19) pandemic, along with recurrent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations and unavailability of specific treatment indicates the need for effective treatments. In this regard, supportive therapies can be highly beneficial and essential. Gastrointestinal microbiome balance has long been considered a vital factor in human health. The use of probiotics has been suggested to treat diseases in which the gut microbiome is imbalanced. Gastrointestinal symptoms are present in some patients with COVID-19, and experiments have shown microbial imbalance in these patients. The inhibition of neutrophil elastase (NE) and an increase in butyrate can help improve and recover COVID-19 by inhibiting virus entry and its proliferation, boosting the immune system, performing antimicrobial functions, and preventing hypercoagulability. Therefore, the possibility of using a combination of Bifidobacterium longum NCC2705, Odoribacter , and Butyricicoccus pullicaecorum 25-3T was proposed for this purpose. In this review article, we discussed the association between the gut microbiome and COVID-19 infection and evaluated the potential of modulating the balance of the gut microbiome in preventing adverse events during SARS-CoV-2 infection.

【 授权许可】

CC BY-NC