HER-3 molecular classification, expression of PD-L1 and clinical importance in breast cancer

Bratislava Medical Journal

article

Libor STANEK¹  Robert GURLICH¹  Adam WHITLEY¹  Petra TESAROVA³  Zdenek MUSIL⁴  Lucie NOVAKOVA² 

[1] Department of Surgery, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University;Third Faculty of Medicine, Charles University in Prague, Department of Histology and Embryology;First Faculty of Medicine, Charles University in Prague, Institute of Oncology;Third Faculty of Medicine, Charles University in Prague, Department of Anatomy

关键词: breast cancer;    HER family;    overexpression;    HER-3;    HER-2;    PD-L1;    TNBC;   

DOI  :  10.4149/BLL_2022_115

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

Receptors of the large HER family play an important role in breast cancer, which is undergoing a gradual development in connection with biological development, both in the fi eld of diagnostics and therapy. Dimerization of HER-2 with other HER members, such as HER-3, is the biggest driver of tumor cell growth and survival. Numerous studies show that HER-3 gene overexpression correlates with poor prognosis. However, other studies have shown HER-3 overexpression to be a positive prognostic factor. HER-3 may confer resistance to certain EGFR or HER-2 receptor therapeutics. An interesting fact, however, is that HER-3 expression can serve as a marker in immunotherapy for triple-negative breast cancer (TNBC). It is thought to be involved not only in cell survival and proliferation, but also in the regulation of PD-L1 expression. In breast cancer, PD-L1 expression is heterogeneous and is generally associated with the presence of tumor-infi ltrating lymphocytes and a number of factors with poor prognosis such as young age, hormone receptor negativity, and high HER-2 expression and proliferation index. Our results showed amplifi cation of HER-3 (CERB3) in 2 out of a sample of 20 patients with TNBC, and 13 of 20 HER-2-positive patients. PD-L1 expression was demonstrated in 3 out of 13 HER-3-positive patients and 2 out of 2 HER-3-positive TNBC patients. There was a strong correlation between positive HER-3 and PD-L1 TNBC expression (p = < 0.001). Thus, the view of the HER-3 receptor will be much more complex, and the overexpression of this receptor appears to have both negative and positive prognostic and clinical impacts.

【 授权许可】

CC BY