Point-of-care diagnosis of COVID-19 disease based on antigen tests

Bratislava Medical Journal

article

M. Pohanka¹ 

[1] Faculty of Military Health Sciences, University of Defense

关键词: coronavirus disease 2019;    diagnosis;    enzyme-linked immunosorbent assay;    immunoassay;    lateral flow test;    SARS-CoV-2;   

DOI  :  10.4149/BLL_2021_122

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

AIMS: This review is focused on the laboratory diagnoses of the coronavirus disease 2019 (COVID-19) by recognizing the antigen of the causative agent SARS-CoV-2 virus. Various antigen tests are available in this moment and these tests are being further developed in order to reach a better diagnostic value. The issue is reviewed in a complex view. METHODS: In this work, a complex survey of the current literature was made. The relevant and recent papers related to antigen tests of COVID-19 are discussed and cited. Basic specifications of the antigen tests and competitive methods were also scrutinized in the current literature. RESULTS: The survey of the current literature (years 2019 ‒ 2021) was made and diagnostic methods like lateral flow tests (lateral flow immunochromatographic assay) and various types of biosensors were specified as tools for COVID-19 diagnosis and their application to be used as a point-of-care test is considered. CONCLUSIONS: Small hand-held assays applicable in the point-of-care conditions for diagnosis of COVID-19 by analysis of SARS-CoV-2 antigen are the means of a growing interest and these means undergo a significant development leading to the improvements of their specifications and applicability to the current praxis. Merit of the assays is discussed in this paper (Tab. 3, Fig. 2, Ref. 109).

【 授权许可】

CC BY