The importance of coenzyme Q10 and its ratio to cholesterol in the progress of chronic kidney diseases linked to non- -communicable diseases

Bratislava Medical Journal

article

A. Gvozdjakova¹  J. Kucharska¹  Z. Sumbalova¹  Z. Rausova¹  A. Chladekova²  M. Komlosi²  M. Szamosova²  V. Mojto² 

[1] Comenius University in Bratislava, Medical Faculty, Pharmacobiochemical Laboratory of 3rd Medical Department;Comenius University in Bratislava, Medical Faculty, 3rd Department of Internal Medicine

关键词: chronic kidney disease;    non-communicable diseases;    glomerular filtration;    creatinine;    coenzyme Q10;    oxidative stress;    index of CoQ10-TOTAL/lipids;   

DOI  :  10.4149/BLL_2020_113

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

OBJECTIVES: The mortality of patients with chronic kidney diseases (CKD) increases with the decrease in glomerular filtration rate (eGFR). In the progress of CKD that is closely linked to non-communicable diseases (NCDs), the role of coenzyme Q10 (CoQ10) is not fully evaluated. We aimed to evaluate the importance of CoQ10, CoQ10/cholesterol ratio, and oxidative stress in the progress of CKD. PATIENTS AND METHODS: The control group was constituted of 19 healthy subjects who volunteered to enrol in the study, CKD group consisted of 58 patients with CKD, of whom 54 had CKD combined with hypertension, 22 had CKD combined with hypertension and diabetes type 2 , and 18 had CKD combined with hypertension and statin therapy. We observed age, BMI, creatinine, uric acid, eGFR, hemoglobin, CRP, glucose, lipids fraction, and liver enzymes. Coenzyme Q10-TOTAL (ubiquinol+ubiquinone) in platelets and plasma were determined using HPLC method with UV detection. Indexed of CoQ10/lipid fractions were evaluated. Oxidative stress was determined as thiobarbituric acid‑reactive substances (TBARS). RESULTS: With increased stages of CKD, eGFR and CoQ10 as well as its ratio to lipids were significantly reduced while TBARS increased. CONCLUSION: We assume that lower endogenous CoQ10 level may be one of the reasons of kidney dysfunction. CoQ10/lipids ratio and increase in oxidative stress can predict the progression of CKD in patients with arterial hypertension, diabetes mellitus and dyslipidemia (Tab. 2, Fig. 4, Ref. 49).

【 授权许可】

CC BY