Urinary megalin in association with progression factors of diabetic nephropathy

Bratislava Medical Journal

article

A. Akour¹  V. Kasabri¹  N. Bulatova¹  Y. Al-Motassem¹  H. Fahmawi¹  M. Momani²  A. Zayed²  R. Alquoqa¹  H. AlHawari³ 

[1] Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, the University of Jordan;Diabetes and Endocrinology Unit, Jordan University Hospital;Nephrology Unit, Jordan University Hospital

关键词: diabetic nephropathy;    progression factors;    biomarker;    type 2 diabetes;    megalin;   

DOI  :  10.4149/BLL_2019_086

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

AIM: The aim of this study is to evaluate the association between urinary megalin, renal function, blood pressure, lipid profile, vitamin D and glycemic control in patients with type 2 diabetes mellitus (T2DM). METHODS:. This was a cross-sectional study which recruited 209 patients with T2DM. Urinary megalin was positively associated with systolic blood pressure (SBP) (r=0.218, p=0.04) but negatively with glomerular filtration rate (GFR) (r=–0.16, p=0.023). The levels of urinary albumin, triglycerides (TGs) and glycosylated hemoglobin (HbA1c) were higher in the “high-megalin” group, compared to those in “low-megalin” group. Moreover, there was a significant inverse association between vitamin D3 levels and megalin levels in urine (OR=0.281, p=0.047). CONCLUSION: Our study showed for the first time that megalin is associated with progression factors of diabetic nephropathy as well as vitamin D deficiency (Tab. 3, Fig. 1, Ref. 15).

【 授权许可】

CC BY