Renal Biopsy in Type 2 Diabetic Patients

Journal of Clinical Medicine

Eugenia Espinel²  Irene Agraz²  Meritxell Ibernon²  Natalia Ramos²  Joan Fort²  Daniel Serón¹  Desirພ Luis² 

[1] Nephrology Department, Hospital Universitari Vall d’Hebron, Autonomous University of Barcelona, Passeig de la Vall d’Hebron 119-129, 08035 Barcelona, Spain;

关键词: diabetic nephropathy;    type 2 diabetes;    kidney biopsy;    histology;   

DOI  :  10.3390/jcm4050998

来源: mdpi

【 摘 要 】

The majority of diabetic patients with renal involvement are not biopsied. Studies evaluating histological findings in renal biopsies performed in diabetic patients have shown that approximately one third of the cases will show pure diabetic nephropathy, one third a non-diabetic condition and another third will show diabetic nephropathy with a superimposed disease. Early diagnosis of treatable non-diabetic diseases in diabetic patients is important to ameliorate renal prognosis. The publication of the International Consensus Document for the classification of type 1 and type 2 diabetes has provided common criteria for the classification of diabetic nephropathy and its utility to stratify risk for renal failure has already been demonstrated in different retrospective studies. The availability of new drugs with the potential to modify the natural history of diabetic nephropathy has raised the question whether renal biopsies may allow a better design of clinical trials aimed to delay the progression of chronic kidney disease in diabetic patients.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.