Voriconazole-induced periostitis post lung transplantation

Radiology Case Reports

article

Orla M. Murray¹  John P Hynes¹  Michelle A Murray¹  Eoin C Kavanagh¹ 

[1] Department of Radiology, Mater Misericordiae University Hospital

关键词: Voriconazole;    Periostitis;    Lung transplantation;   

DOI  :  10.1016/j.radcr.2022.01.078

学科分类：生物化学工程

来源: University of Washington * Department of Radiology

【 摘 要 】

Voriconazole is a broad-spectrum triazole antifungal used to treat invasive fungal infections . It is commonly used prophylactically in immunocompromized patient cohorts, including transplant recipients. Diffuse periostitis is a very rare complication of chronic voriconazole use. It is associated with diffuse bone pain, elevated serum alkaline phosphatase and fluorine levels. Characteristic imaging findings include periosteal thickening with a dense, nodular, irregular and often bilateral pattern. We describe the case of a 71-year-old female who presented with multifocal bone pain six years following double lung transplantation . Her post transplantation course had been complicated by a life threatening episode of sepsis secondary to Scedosporium apiospermum, a rare invasive fungal infection following which lifelong prophylaxis with oral Voriconazole was commenced. We discuss the characteristic clinical and imaging manifestations of this rare condition.

【 授权许可】

CC BY|CC BY-NC-ND