Stem cell research | |
Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients caused by heterozygous mutations in the HCN4 gene | |
article | |
Zehra Yildirim1  Ana Kojic1  Christopher D. Yan1  Matthew A. Wu1  Randall Vagelos2  Joseph C. Wu1  | |
[1] Stanford Cardiovascular Institute, Stanford University School of Medicine;Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine;Department of Radiology, Stanford University School of Medicine | |
关键词: Dilated cardiomyopathy; iPSC; Stem cells; HCN4; | |
DOI : 10.1016/j.scr.2022.102951 | |
学科分类:生理学 | |
来源: Academic Press | |
【 摘 要 】
Dilated cardiomyopathy (DCM) is a progressive heart muscle disease that can culminate with heart failure and death. Mutations in several genes can cause DCM, including hyperpolarization-activated cyclic nucleotide-gated channel (HCN4), which has a critical function in the autonomic control of the heart rate. Here, we generated two human induced pluripotent stem cell (iPSC) lines generated from two DCM patients carrying variants in the HCN4 gene (c.2587G > T and c.2846G > A). Both lines display normal karyotype, typical morphology of pluripotent stem cells, and differentiate into all three germ layers in vitro . These lines are valuable resources for studying the pathological mechanisms of DCM.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202302100002257ZK.pdf | 2943KB | download |