期刊论文详细信息
Stem cell research | |
Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients | |
article | |
Arianne Caudal1  Gema Mondejar-Parreño1  Carlos D. Vera1  Damon R. Williams1  Sushma P. Shenoy1  David Liang3  Joseph C. Wu1  | |
[1] Stanford Cardiovascular Institute, Stanford University School of Medicine;Cardiovascular Medicine, Stanford University School of Medicine;Department of Radiology, Stanford University School of Medicine | |
关键词: iPSC; Stem cell; Dilated cardiomyopathy; Phospholamban; | |
DOI : 10.1016/j.scr.2022.102855 | |
学科分类:生理学 | |
来源: Academic Press | |
【 摘 要 】
Familial dilated cardiomyopathy (DCM) is among the most prevalent forms of inherited heart disease. Here, two human-induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) from DCM patients carrying different mutations in the phospholamban encoding-gene (PLN). Both iPSC lines exhibited normal morphology, karyotype, pluripotency marker expression, and differentiation into the three germ layers. These patient-specific iPSC lines serve as valuable in vitro models for DCM pathology caused by PLN mutations.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202302100002159ZK.pdf | 5915KB | download |