Generation and characterisation of four multiple sclerosis iPSC lines from a single family

Stem cell research

article

Alastair J. Fortune¹  Bruce V. Taylor¹  Jac C. Charlesworth¹  Kathryn P. Burdon¹  Nicholas B. Blackburn¹  Jessica L. Fletcher¹  Ashish Mehta¹  Kaylene M. Young¹ 

[1] Menzies Institute for Medical Research, University of Tasmania

关键词: Induced pluripotent stem cells;    Multiple sclerosis;    Neurodegenerative disease;    Reprogramming;   

DOI  :  10.1016/j.scr.2022.102828

学科分类：生理学

来源: Academic Press

【 摘 要 】

Multiple sclerosis (MS) is a complex neuroinflammatory/degenerative disease of the central nervous system (CNS) that results in the formation of demyelinated lesions and axon degeneration. MS aetiology is complex, with genetics estimated to account for ∼48% of MS risk ( International Multiple Sclerosis Genetics Consortium, 2019 ). Despite this, families with a high incidence of MS are rare. We have generated four induced pluripotent stem cell (iPSC) lines from individuals with relapsing-remitting and secondary progressive MS within a single family. The generation of disease-specific iPSC lines from multiple members of a single family will facilitate MS genetic and functional studies.

【 授权许可】

CC BY|CC BY-NC-ND