Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis

eJHaem

article

Patricia García-Abellás¹  Ana Ferrer Gómez¹  Diego Bueno Sacristán¹  Miguel Piris Villaespesa²  María Talavera Yagüe³  María Eugenia Reguero Callejas¹  Mónica García-Cosío⁴ 

[1] Department of Pathology, Ramón y Cajal Universitary Hospital;Department of Hematology, Ramón y Cajal Universitary Hospital;Department of Genetics, Ramón y Cajal Universitary Hospital;Head of Hematopathology Department, Ramón y Cajal Universitary Hospital;Alcalá University;Instituto Ramon y Cajal de Investigacion Sanitaria;CIBERONC

关键词: bone marrow;    diagnosis;    lymphoplasmacytic lymphoma;    marginal zone lymphoma;    Waldenström macroglobulinemia;   

DOI  :  10.1002/jha2.573

来源: Wiley

【 摘 要 】

Lymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL) frequently infiltrate the bone marrow with similar histologic and immunohistochemical characteristics posing diagnostic problems. Bone marrow biopsy specimens from 25 LPL and 16 MZL have been studied, correlating with clinical, laboratory parameters and the MYD88_p.L265P mutation. Paratrabecular and interstitial infiltration pattern, serum IgM paraprotein levels, and MYD88_p.L265P mutation were significantly more frequent in LPL. Nodular or intrasinusoidal pattern with lymphocytosis and splenomegaly were associated with MZL diagnosis. Different clinical and histological parameters should be collected when LPL or MZL is suspected in bone marrow biopsy specimens.

【 授权许可】

Unknown