期刊论文详细信息
eJHaem | |
COVID-19-associated secondary hemophagocytic lymphohistiocytosis requiring hematopoietic cell transplant | |
article | |
Jacob R. Greenmyer1  Kirk D Wyatt2  Sam Milanovich2  Mira A. Kohorst3  Asmaa Ferdjallah3  | |
[1]Pediatric and Adolescent Medicine, Mayo Clinic | |
[2]Pediatric Hematology and Oncology, Sanford Health | |
[3]Pediatric Hematology and Oncology, Mayo Clinic | |
关键词: hematology; infection; pediatrics; stem cell transplantation; thrombocytopenia; | |
DOI : 10.1002/jha2.456 | |
来源: Wiley | |
![]() |
【 摘 要 】
Coronavirus disease 2019 (COVID-19) infection causes a variety of extrapulmonary complications in pediatric patients. Multisystem inflammatory syndrome and hemophagocytic lymphohistiocytosis (HLH) are related to hypercytokinemia in COVID-19 patients. HLH is a disorder of exaggerated inflammation resulting in a cytokine storm and unrestricted hemophagocytosis. HLH can be primary (familial) or secondary (acquired). Secondary HLH (sHLH) can occur in patients with rheumatologic, oncologic, or infectious diseases. The link between COVID-19 and HLH has been reported in pediatric patients. Here we report a case of a pediatric patient who developed refractory sHLH secondary to COVID-19 infection and required a hematopoietic cell transplant for the cure.【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202302050005870ZK.pdf | 267KB | ![]() |