Alcohol and tobacco use and risk of multiple myeloma: A case-control study

eJHaem

article

Simon Cheah¹  Julie K. Bassett¹  Fiona J. Bruinsma¹  Wendy Cozen³  John L. Hopper²  Harindra Jayasekara¹  Douglas Joshua⁴  Robert J. MacInnis¹  H. Miles Prince⁵  Claire M. Vajdic⁷  Marina T. van Leeuwen⁷  Nicole Wong Doo⁸  Simon J. Harrison⁵  Dallas R. English¹  Graham G. Giles¹  Roger L. Milne¹ 

[1]Cancer Epidemiology Division

[2]Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne

[3]Department of Preventive Medicine, University of Southern California

[4]Royal Prince Alfred Hospital, Sydney Medical School, University of Sydney

[5]Sir Peter MacCallum Department of Oncology, University of Melbourne

[6]Epworth Healthcare

[7]Centre for Big Data Research in Health, The University of New South Wales

[8]Concord Clinical School, University of Sydney

[9]Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital

[10]School of Clinical Sciences at Monash Health, Precision Medicine, Monash University

关键词: alcohol;    epidemiology;    family case–control study;    multiple myeloma;    smoking;   

DOI  :  10.1002/jha2.337

来源: Wiley

【 摘 要 】

Multiple myeloma (MM) is the second most common hematological cancer and causes significant mortality and morbidity. Knowledge regarding modifiable risk factors for MM remains limited. This analysis of an Australian population-based case–control family study investigates whether smoking or alcohol consumption is associated with risk of MM and related diseases. Incident cases ( n  = 789) of MM were recruited via cancer registries in Victoria and New South Wales. Controls ( n  = 1,113) were either family members of cases ( n  = 696) or controls recruited for a similarly designed study of renal cancers ( n  = 417). Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional multivariable logistic regression. Heavy intake (>20 g ethanol/day) of alcohol had a lower risk of MM compared with nondrinkers (OR = 0.68, 95% CI: 0.50–0.93), and there was an inverse dose–response relationship for average daily alcohol intake (OR per 10 g ethanol per day = 0.92, 95% CI: 0.86–0.99); there was no evidence of an interaction with sex. There was no evidence of an association with MM risk for smoking-related exposures ( p  > 0.18). The associations between smoking and alcohol with MM are similar to those with non-Hodgkin lymphoma. Further research into potential underlying mechanisms is warranted.

【 授权许可】

Unknown