CANOMAD unmasked by COVID-19 in a man with Waldenström's macroglobulinaemia

eJHaem

article

Hamish D. Morrison¹  Jonathan Cleaver¹  Natasha Lander¹  Philippa Lowden¹  Kate Hale¹  Kanchan Sharma¹  James Stevens¹ 

[1] Neurology Department;Population Health Sciences, University of Bristol

关键词: cold agglutinin;    immunoglobulin;    neuropathy;    WM;   

DOI  :  10.1002/jha2.210

来源: Wiley

【 摘 要 】

CANOMAD is a rare syndrome encompassing chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, cold agglutinins and disialosylantibodies [1,2]. We present a case of acute craniobulbar palsy associated with COVID-19 in which the combination of an established IgMparaprotein and the later emergence of a typical and persistent ganglioside antibody profile ultimately revealed a diagnosis of CANOMADsyndrome.We review the clinical presentation, diagnostic work-up andcurrent treatment.

【 授权许可】

Unknown