Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

Cancer Communications

article

Valdenizia R. Silva¹  Luciano de S. Santos¹  Rosane B. Dias¹  Claudio A. Quadros²  Daniel P. Bezerra¹ 

[1] Gonçalo Moniz Institute, Oswaldo Cruz Foundation;São Rafael Hospital;Bahia State University

关键词: colorectal;    cancer stem cells;    cell signaling;    Wnt/β-catenin pathway;    Notch;    Hedgehog;    NF-κB;    JAK/STAT signaling;    PI3K/Akt/mTOR signaling;    targeted therapy;   

DOI  :  10.1002/cac2.12235

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripotency and self-renewal properties. These cells are considered responsible for the progression of the disease, recurrence and tumor resistance. Interestingly, some cell signaling pathways participate in CRC survival, proliferation, and self-renewal properties, and most of them are dysregulated in CSCs, including the Wingless (Wnt)/β-catenin, Notch, Hedgehog, nuclear factor kappa B (NF-κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), peroxisome proliferator-activated receptor (PPAR), phosphatidyl-inositol-3-kinase/Akt/mechanistic target of rapamycin (PI3K/Akt/mTOR), and transforming growth factor-β (TGF-β)/Smad pathways. In this review, we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways, which will contribute to the study of potential therapeutic schemes, combining conventional drugs with CSC-targeting drugs, and allowing better cure rates in anti-CRC therapy.

【 授权许可】

CC BY|CC BY-NC-ND