期刊论文详细信息
Laryngoscope Investigative Otolaryngology
Treatment failure patterns are similar between p16− and p16+ oropharyngeal squamous cell carcinomas
article
Chelsea S. Hamill MD1  Richard Grant Muller MD1  Kate Clancy MD1  Brandon Vu BS2  Shanying Gui PhD2  Jason Eric Thuener MD1  Jay Wasman MD2  Shawn Li MD1  Nicole Fowler MD1  Rod Rezaee MD1  Pierre Lavertu MD1  Theodoros N. Teknos MD1  Quintin Pan PhD1  Wendi Quinn O'Neill MS, DDS1 
[1] Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine;University Hospitals Seidman Cancer Center;Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine;Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine
关键词: disease progression;    head and neck cancer;    oropharyngeal cancer;    p16;    treatment failure;   
DOI  :  10.1002/lio2.779
学科分类:环境科学(综合)
来源: Wiley
PDF
【 摘 要 】

Background The incidence of p16+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing. The notion that p16+ OPSCC has a propensity for atypical and disseminating metastasis has gained traction. We compared treatment failure patterns in p16+ and p16− OPSCC and evaluated survival impact. Methods Retrospective analysis of patients with recurrent/metastatic OPSCC disease between 1/2009 and 12/2019. Results Thirty-eight p16+ and 36 p16− patients were identified. Three distinct failure patterns (distant vs. locoregional, atypical vs. typical, and disseminating vs. non-disseminating) were studied. No significant differences were found between p16+ and p16− patients. Multivariate analysis showed p16 status was an independent prognostic biomarker; p16+ patients have a favorable overall survival compared to p16− patients (HR 0.34, 95% CI 0.16–0.77; P  = .005). Conclusions We challenge the view that p16+ OPSCC exhibits a distinctive treatment failure pattern and showed that p16 status impacts patient survival independent of disease progression.

【 授权许可】

CC BY|CC BY-NC-ND   

【 预 览 】
附件列表
Files Size Format View
RO202302050004326ZK.pdf 1432KB PDF download
  文献评价指标  
  下载次数:2次 浏览次数:0次