Non-Robustness of Ang’s Risk Classification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma in Japanese Patients

Cancers

Yuko Kubo¹  Yoshitaka Honma²  Go Omura³  Fumihiko Matsumoto³  Kenya Kobayashi³  Seiichi Yoshimoto³  Taisuke Mori⁴  Jun Itami⁵  Kae Okuma⁵  Ayaka Takahashi⁵  Tairo Kashihara⁵  Hiroshi Igaki⁵  Koji Inaba⁵  Yuri Shimizu⁵  Kana Takahashi⁵  Naoya Murakami⁵  Yuko Nakayama⁵ 

[1] Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo 104-0045, Japan;Department of Head and Neck Medical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan;Department of Head and Neck Surgical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan;Department of Pathology, National Cancer Center Hospital, Tokyo 104-0045, Japan;Department of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan;

关键词: oropharyngeal cancer;    squamous cell cancer;    human papillomavirus;    p16;    risk classification;    prognosis;   

DOI  :  10.3390/cancers14102442

来源: DOAJ

【 摘 要 】

Background: Validity of the risk classification by Ang for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) remains to be studied in the patients treated by modalities other than chemoradiotherapy and in Japanese patients. Materials and Methods: Between 2010 and 2018, 122 patients with HPV-related OPSCC in stages III and IV by the TNM classification 7th edition (TNM-7) were treated curatively at a single institution in Japan. The median age was 62.7 years. Over 50% of the patients underwent surgery with or without adjuvant therapy. The influence of multiple factors on survival was analyzed. Results: The amount of smoking dichotomized at 10 pack-year, which was used in Ang’s risk classification, was not predictive of prognosis, and Ang’s risk classification was not significantly influential on prognosis in multivariate analysis. In the patients treated with definitive radiation therapy, Ang’s risk classification was not predictive of the prognosis in univariate analysis. The impact of smoking was significant only in the patients undergoing the definitive operation. Conclusions: Ang’s risk classification was not robust in predicting the prognosis of general Japanese HPV-related OPSCC patients. The amount of smoking might have different prognostic influences depending on the therapeutic method.

【 授权许可】

Unknown