Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media

Laryngoscope Investigative Otolaryngology

article

Wan Nur Anis Wan Draman MD¹  Mohd Khairi Md Daud MMed (ORL-HNS)¹  Hazama Mohamad MMed (ORL-HNS)¹  Siti Asma Hassan MPath (Microbiology)³  Normastura Abd Rahman MCommMed⁴ 

[1] Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia;Otorhinolaryngology-Head and Neck Surgery Specialist Clinic, Hospital Universiti Sains Malaysia;Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia;School of Dental Sciences, Universiti Sains Malaysia

关键词: antibiotic sensitivity;    bacterial profile;    chronic suppurative otitis media;   

DOI  :  10.1002/lio2.682

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objective To determine the current microbiological profile of chronic suppurative otitis media (CSOM), their antimicrobial sensitivity, their resistance pattern to locally available antibiotics and the appropriate antibiotic against isolated microorganisms causing CSOM. Methods This cross-sectional study involved 91 ear swab specimens obtained from patients clinically diagnosed with active CSOM. Swabs were cultured for microbial identification according to a standard protocol. We performed antibiotic susceptibility testing, using the modified Kirby-Bauer disc diffusion method, and the diameter of the inhibition zone was interpreted based Clinical Laboratory Standards Institute guidelines. Results Microbial growth was seen in 85 (93.4%) samples, but 6 (6.6%) samples had no growth. Among the samples with growth, 63 (69.2%) were monomicrobial, 13 (14.3%) were polymicrobial, and 9 (9.9%) were of mixed growth with more than three microorganisms. The most common bacteria isolated was Pseudomonas aeruginosa (32.6%) followed by Staphylococcus aureus (16.9%) and Klebsiella spp. (5.6%). The most sensitive antibiotics against P aeruginosa were ceftazidime, meropenem, piperacillin-tazobactam, and cefepime. S aureus showed the highest sensitivity toward rifampin, cefoxitin, and fusidic acid. Conclusions The bacteriological profile of CSOM showed a high prevalence of P aeruginosa , followed by S aureus and Klebsiella spp. with different distributions in different age groups. We observed a declining pattern of their antibiotic sensitivity. It is important to be aware of the current trend of the bacteriological profiles and to revise the antibiotic regime according to both the sensitivity and age groups. Level of Evidence: NA.

【 授权许可】

CC BY|CC BY-NC-ND