Effects of hypertonic alkaline nasal irrigation on COVID-19

Laryngoscope Investigative Otolaryngology

article

Yetkin Zeki Yilmaz MD¹  Begum Bahar Yilmaz MD²  Yusuf Emre Ozdemir MD³  Bekir Sami Kocazeybek MD⁴  Ridvan Karaali MD⁵  Doğan Çakan MD¹  Hasan Ahmet Ozdogan MD¹  Aysegul Batioglu-Karaaltin MD¹ 

[1] Department of Otorhinolaryngology, Cerrahpasa Faculty of Medicine, Istanbul University—Cerrahpasa;Department of Otorhinolaryngology, Istanbul Basaksehir Cam and Sakura City Hospital, Republic of Turkey Ministry of Health;Department of Infectious Diseases and Clinical Microbiology, Dr Sadi Konuk Training and Research Hospital, Republic of Turkey Ministry of Health;Department of Microbiology, Cerrahpasa Faculty of Medicine, Istanbul University—Cerrahpasa;Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Faculty of Medicine, Istanbul University—Cerrahpasa

关键词: alkaline hypertonic solutions;    COVID-19;    nasal lavage;    nasal sprays;    quantitative PCR;   

DOI  :  10.1002/lio2.686

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objective The causative agent of COVID-19 is a novel member of coronaviridaes, SARS-CoV-2. It has been reported that the spike (S) protein of SARS-CoV-2 is responsible of infectivity. The S protein is demonstrated to be inactivated under environmental condition, such as hypertonicity and alkaline pH. The aim of the study was to investigate the effect of hypertonic alkaline nasal irrigation (HANI) on SARS-CoV-2. Methods Sixty patients divided into two groups. The patients in Group 1 used hydroxychloroquine (HCQ), and the patients in Group 2 used HCQ and HANI. Nasopharyngeal samples were collected at the beginning, on 3rd and 7th day of the PCR test positivity. The nasopharyngeal viral load (NVL) changes analyzed with quantitative PCR. Results NVL decrease in weekly period was statistically significant for both groups, when the difference between NVL day 0 and 3rd in Group 1 and NVL difference between day 0 and 3rd in Group 2 were compared. The difference between Groups 1 and 2 in terms of NVL change was statistically significant ( P  < 0.05). Conclusion We demonstrated a significant decrease in nasopharyngeal SARS-CoV-2 load with HANI solution and suggest that HANI may be promising modality for the COVID-19 treatment.

【 授权许可】

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