Quality of life after radiation and transoral robotic surgery in advanced oropharyngeal cancer

Laryngoscope Investigative Otolaryngology

article

Thomas M. Kaffenberger¹  Ankur K. Patel²  Lingyun Lyu³  Jinhong Li³  Tamara Wasserman-Wincko¹  Dan P. Zandberg⁴  David A. Clump²  Jonas T. Johnson¹  Marci L. Nilsen¹ 

[1] Department of Otolaryngology—Head and Neck Surgery, University of Pittsburgh School of Medicine;Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine;Department of Biostatistics, University of Pittsburgh School of Public Health;Department of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine;Department of Acute and Tertiary Care, University of Pittsburgh School of Nursing

关键词: oropharyngeal cancer;    quality of life;    robotic surgery;    survivorship;    TORS;   

DOI  :  10.1002/lio2.628

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objectives Oropharyngeal squamous cell carcinoma (OPSCC) treatment results in impaired swallowing and quality of life (QOL). We analyzed a cross-section of advanced stage OPSCC patients treated with multimodal therapies at our Survivorship Clinic to investigate treatment factors associated with QOL. Methods Retrospective analysis of patient-reported outcomes (PROMs) after primary OPSCC treatment using AJCC seventh edition staging. Results A total of 73 patients were included (90.1% human papillomavirus positive [HPV+]). There were no QOL differences between robotic surgery with radiation ±  chemotherapy patients (n = 29) and those treated by radiation  ±  chemotherapy (n = 44). Radiation field analysis demonstrated significant correlations between increasing doses to larynx and contralateral parotid and submandibular gland and worse swallowing as measured by the Eating Assessment Tool-10 ( P  = .02; P  = .01; P  = .01). Conclusions In advanced, mostly HPV+, OPSCC, we did not find clinically significant differences between QOL PROMs between surgical and radiation  ±  chemotherapy treatment groups. This highlights the need for continued therapy de-escalation along with improved interventions for treatment related toxicities. Level of evidence 4.

【 授权许可】

CC BY|CC BY-NC-ND