Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Cross-reactive cellular, but not humoral, immunity is detected between OC43 and SARS-CoV-2 NPs in people not infected with SARS-CoV-2: Possible role of cT FH cells | |
article | |
Álvaro Fernando García-Jiménez1  Yaiza Cáceres-Martell1  Daniel Fernández-Soto1  Pedro Martínez Fleta2  José M. Casasnovas3  Francisco Sánchez-Madrid2  José Miguel Rodríguez Frade1  Mar Valés-Gómez1  Hugh T. Reyburn1  | |
[1] Department of Immunology and Oncology, National Centre for Biotechnology;Immunology Department, Hospital Universitario La Princesa IIS-IP;Department of Macromolecular Structures, National Centre for Biotechnology | |
关键词: COVID-19; cross-reactive immunity; HCoV-OC43; SARS-CoV-2; | |
DOI : 10.1002/JLB.4COVCRA0721-356RRR | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Multiple questions about SARS-CoV-2 humoral and cellular immunity remain unanswered. One key question is whether preexisting memory T or B cells, specific for related coronaviruses in SARS-CoV-2-unexposed individuals, can recognize and suppress COVID-19, but this issue remains unclear. Here, we demonstrate that antibody responses to SARS-CoV-2 antigens are restricted to serum samples from COVID-19 convalescent individuals. In contrast, cross-reactive T cell proliferation and IFN-γ production responses were detected in PBMCs of around 30% of donor samples collected prepandemic, although we found that these prepandemic T cell responses only elicited weak cT FH activation upon stimulation with either HCoV-OC43 or SARS-CoV-2 NP protein. Overall, these observations confirm that T cell cross-reactive with SARS-CoV-2 antigens are present in unexposed people, but suggest that the T cell response to HCoV-OC43 could be deficient in some important aspects, like T FH expansion, that might compromise the generation of cross-reactive T FH cells and antibodies. Understanding these differences in cellular responses may be of critical importance to advance in our knowledge of immunity against SARS-CoV-2.
【 授权许可】
CC BY
【 预 览 】
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RO202302050003883ZK.pdf | 1472KB | download |