Crosstalk between R848 and abortive HIV-1 RNA-induced signaling enhances antiviral immunity

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Melissa Stunnenberg¹  John L. van Hamme¹  Esther M. Zijlstra-Willems¹  Sonja I. Gringhuis¹  Teunis B.H. Geijtenbeek¹ 

[1] Department of Experimental Immunology, Amsterdam institute for Infection & Immunity, Amsterdam UMC, University of Amsterdam

关键词: adaptive immunity;    immunomodulation;    innate immunity;    pathogen-associated molecular pattern;    pattern recognition receptor;    TLR8;   

DOI  :  10.1002/JLB.4A0721-365R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Pathogens trigger multiple pattern recognition receptors (PRRs) that together dictate innate and adaptive immune responses. Understanding the crosstalk between PRRs is important to enhance vaccine efficacy. Abortive HIV-1 RNA transcripts are produced during acute and chronic HIV-1 infection and are known ligands for different PRRs, leading to antiviral and proinflammatory responses. Here, we have investigated the crosstalk between responses induced by these 58 nucleotide-long HIV-1 RNA transcripts and different TLR ligands. Costimulation of dendritic cells (DCs) with abortive HIV-1 RNA and TLR7/8 agonist R848, but not other TLR agonists, resulted in enhanced antiviral type I IFN responses as well as adaptive immune responses via the induction of DC-mediated T helper 1 (T H 1) responses and IFNγ + CD8 + T cells. Our data underscore the importance of crosstalk between abortive HIV-1 RNA and R848-induced signaling for the induction of effective antiviral immunity.

【 授权许可】

CC BY