Metabolic reprogramming of myeloid-derived suppressor cells: An innovative approach confronting challenges

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Xiaoqing Li¹  Yixue Li¹  Qinru Yu¹  Pengxu Qian²  He Huang¹  Yu Lin¹ 

[1] Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University;Institute of Hematology, Zhejiang University;Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy;Liangzhu Laboratory, Zhejiang University Medical Center

关键词: MDSCs;    metabolic reprogramming;    immune homeostasis;    microenvironment;   

DOI  :  10.1002/JLB.1MR0421-597RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Immune cells such as T cells, macrophages, dendritic cells, and other immunoregulatory cells undergo metabolic reprogramming in cancer and inflammation-derived microenvironment to meet specific physiologic and functional demands. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are characterized by immunosuppressive activity, which plays a key role in host immune homeostasis. In this review, we have discussed the core metabolic pathways, including glycolysis, lipid and fatty acid biosynthesis, and amino acid metabolism in the MDSCs under various pathologic situations. Metabolic reprogramming is a determinant of the phenotype and functions of MDSCs, and is therefore a novel therapeutic possibility in various diseases.

【 授权许可】

CC BY