Genome-wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy

FEBS Letters

article

Fangfang Wang¹  Jieqiong Zhao¹  Mingming Zhang¹  Jingxiao Yang¹  Guangwei Zeng¹ 

[1] Department of Cardiology, The Second Affiliated Hospital of Air Force Medical University;Department of Cardiology, Xi'an International Medical Center Hospital, Northwest University

关键词: cardiac development;    cardiac hypertrophy;    gene family;    genomics;    LIM domain;   

DOI  :  10.1002/1873-3468.14168

来源: John Wiley & Sons Ltd.

【 摘 要 】

LIM-domain proteins have been shown to be associated with heart development and diseases. Systematic studies of LIM family members at the genome-wide level, which are crucial to further understand their functions in cardiac hypertrophy, are currently lacking. Here, 70 LIM genes were identified and characterised in mice. The expression patterns of LIM genes differ greatly during cardiac development and in the case of hypertrophy. Both Crip2 and Xirp2 are differentially expressed in cardiac hypertrophy and during heart failure. In addition, the hypertrophic state of cardiomyocytes is controlled by the relative expression levels of Crip2 and Xirp2. This study provides a foundation for further understanding of the special roles of LIM proteins in mammalian cardiac development and hypertrophy.

【 授权许可】

Unknown