Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression

FEBS Letters

article

Ruidan Xu¹  Yongfeng Yang¹  Xiaofeng Zheng¹ 

[1] State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University;Department of Biochemistry and Molecular Biology, School of Life Sciences, Peking University

关键词: adenylate kinase;    ATPase;    breast cancer;    Cajal bodies;    colorectal cancer;    DNA damage response;    genome stability;    immunity dysfunction;    leukemia;    signaling pathway regulation;   

DOI  :  10.1002/1873-3468.14158

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human coilin-interacting nuclear ATPase protein (hCINAP), also known as adenylate kinase 6 (AK6), is an atypical adenylate kinase with critical roles in many biological processes, including gene transcription, ribosome synthesis, cell metabolism, cell proliferation and apoptosis, DNA damage responses, and genome stability. Furthermore, hCINAP/AK6 dysfunction is associated with cancer and various inflammatory diseases. In this review, we summarize the structural features and biological roles of hCINAP in several important signaling pathways, as well as its connection with tumor onset and progression.

【 授权许可】

Unknown