Serum levels of the IgA isotype switch factor TGF-β1 are elevated in patients with COVID-19

FEBS Letters

article

Er-yi Wang¹  Hao Chen³  Bao-qing Sun⁵  Hui Wang⁶  Hui-Qi Qu⁷  Yichuan Liu⁷  Xi-zhuo Sun²  Jingchun Qu⁷  Zhang-fu Fang¹  Lifeng Tian⁷  Yi-feng Zeng⁵  Shau-Ku Huang¹  Hakon Hakonarson⁷  Zhi-gang Liu¹ 

[1] Shenzhen Key Laboratory of Allergy & Immunology, State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine;Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University;Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology;State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University;State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University;Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology;Center for Applied Genomics, The Children’s Hospital of Philadelphia;National Health Research Institutes;Division of Human Genetics & Division of Pulmonary Medicine, Children’s Hospital of Philadelphia

关键词: COVID-19;    IgA;    TGF-β1;    SARS-CoV-2;   

DOI  :  10.1002/1873-3468.14104

来源: John Wiley & Sons Ltd.

【 摘 要 】

We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-β1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-β1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE II score in patients with severe disease. In view of the genetic association of the TGF-β1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative, this study suggests TGF-β1 may play a key role in COVID-19.

【 授权许可】

Unknown