Impact of abnormal karyotype on reproductive outcome in premature ovarian insufficiency

Reproductive medicine and biology

article

Leonti Grin¹  Bunpei Ishizuka³  Asami Onimaru³  Masataka Furuya³  Kazuhiro Kawamura¹ 

[1] Advanced Reproductive Medicine Research Center, International University of Health and Welfare School of Medicine;Assisted Reproductive Technology Unit, Barzilai University Medical Center, Ben-Gurion University of the Negev;Rose Ladies Clinic

关键词: chromosomal abnormalities;    controlled ovarian hyperstimulation;    karyotype;    premature ovarian insufficiency;    turner syndrome;   

DOI  :  10.1002/rmb2.12471

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose This study evaluated the reproductive potential of premature ovarian insufficiency (POI) patients with abnormal karyotypes undergoing infertility treatments. Methods A retrospective analysis of infertility treatments in POI patients with an abnormal karyotype treatment. Clinical and laboratory data were analyzed. Results The study group was forty-nine POI patients. Follicular growth was achieved in 29% (89/307) controlled ovarian stimulation (COS) cycles in 57% (28/49) of patients. Oocyte retrieval was attempted in 47% (23/49) of patients with a proportion of successful oocyte retrieval per oocyte pick-up (OPU) of 59.4% (41/69). The average number of retrieved oocytes was 2.4 ± 2.7 per patient and fertilization rate was 70.7% (29/41). Embryo transfer (ET) performed in eight patients with a total of nine ET attempts, resulting in 33.3% (3/9) of live birth rate per ET. Three patients delivered a healthy baby (6.1% (3/49) of live birth rate per patient). Mosaic Turner syndrome patients had a longer duration of amenorrhea and lower chances of successful follicular growth with OPU in 35.7% (5/14) of patients, whereas 47XXX had shorter duration of amenorrhea and COS with follicle growth with OPU in 83.3% (5/6). Conclusion COS might provide an opportunity for POI women with abnormal karyotypes to conceive a biological offspring.

【 授权许可】

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