Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages

The Pan African Medical Journal

Imen Chemkhi¹  Islem Messaoudi¹  Zouhour Belghith¹  Rim Obay¹  Wajih Hammami¹  Wiem Ayed¹  Nabila Abidli¹  Helmy Guermani¹  Ahlem Amouri¹ 

[1] Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisia;

关键词: recurrent miscarriage;    chromosomal abnormalities;    karyotype;   

DOI  :  10.11604/pamj.2017.28.99.11879

来源: DOAJ

【 摘 要 】

Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses before 24 weeks of gestation. Parental chromosomal abnormalities represent an important etiology of RM. The aim of the present study was to identify the distribution of chromosome abnormalities among Tunisian couples with RM referred to the Department of Cytogenetic at the Pasteur Institute of Tunis (Tunisia) during the last five years. Standard cytogenetic analysis was carried out in a total of 163 couples presenting with two or more spontaneous abortions. Karyotypes were analyzed by R-banding. We identified 14 chromosomal abnormalities including autosomal reciprocal translocation, Robertsonian translocation, inversion, mosaic aneuploidy and heteromorphysm. The overall prevalence of chromosomal abnormalities was 8.5% in our cohort. This finding underlies the importance of cytogenetic investigations in the routine management of RM.

【 授权许可】

Unknown