Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview

Epigenetics Insights

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PADS Palihaderu¹  BILM Mendis¹  JMKJK Premarathne²  WKRR Dias³  Swee Keong Yeap⁴  Wan Yong Ho⁵  AS Dissanayake⁶  IH Rajapakse⁷  P Karunanayake⁸  U Senarath⁹  DA Satharasinghe¹ 

[1] Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya;Department of Livestock and Avian Sciences, Faculty of Livestock, Fisheries, and Nutrition, Wayamba University of Sri Lanka;Department of North Indian Music, Faculty of Music, University of the Visual and Performing Arts;China-ASEAN College of Marine Sciences, Xiamen University Malaysia Campus;Division of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham ,(Malaysia Campus);Department of Clinical Medicine, Faculty of Medicine, University of Ruhuna;Department of Psychiatry, Faculty of Medicine, University of Ruhuna;Department of Clinical Medicine, Faculty of Medicine, University of Colombo;Department of Community Medicine, Faculty of Medicine, University of Colombo

关键词: miRNA;    therapeutic;    miRNA-mimics;    antimiRs;    metabolism;    beta-cell differentiation;   

DOI  :  10.1177/25168657221130041

学科分类：兽医学

来源: Tu Delft Transport Institute

【 摘 要 】

MicroRNA(miRNA)s have been identified as an emerging class for therapeutic interventions mainly due to their extracellularly stable presence in humans and animals and their potential for horizontal transmission and action. However, treating Type 2 diabetes mellitus using this technology has yet been in a nascent state. MiRNAs play a significant role in the pathogenesis of Type 2 diabetes mellitus establishing the potential for utilizing miRNA-based therapeutic interventions to treat the disease. Recently, the administration of miRNA mimics or antimiRs in-vivo has resulted in positive modulation of glucose and lipid metabolism. Further, several cell culture-based interventions have suggested beta cell regeneration potential in miRNAs. Nevertheless, few such miRNA-based therapeutic approaches have reached the clinical phase. Therefore, future research contributions would identify the possibility of miRNA therapeutics for tackling T2DM. This article briefly reported recent developments on miRNA-based therapeutics for treating Type 2 Diabetes mellitus, associated implications, gaps, and recommendations for future studies.

【 授权许可】

CC BY|CC BY-NC