Kynurenine and Anthranilic Acid in the Peritoneum Correlate With the Stage of Gastric Cancer Disease

International Journal of Tryptophan Research

article

Yuhei Yajima¹  Alato Okuno²  Isamu Nakamura³  Teruo Miyazaki⁴  Akira Honda⁴  Atsushi Toyoda¹ 

[1] Department of Food and Life Sciences, College of Agriculture, Ibaraki University;Department of Health and Nutrition, Faculty of Human Design, Shibata Gakuen University;Department of Occupational Therapy, Ibaraki Prefectural University of Health Sciences;Joint Research Center, Tokyo Medical University Ibaraki Medical Center;United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology

关键词: Feed;    kynurenine;    hippocampus;    urine metabolome;    peripheral metabolites;   

DOI  :  10.1177/11786469211066285

学科分类：生理学与病理学

来源: Sage Journals

【 摘 要 】

The kynurenine (Kyn) pathway plays crucial roles in several inflammation-induced disorders such as depression. In this study, we measured Kyn and other related molecules in the blood plasma, brain, and urine of male C57BL/6J mice (B6) fed non-purified (MF) and semi-purified (AIN-93G and AIN-93M) standard rodent diets. Mice fed MF had increased plasma Kyn levels compared with those on AIN93-based diets, as well as decreased hippocampal Kyn levels compared with those fed AIN-93G. Previous studies showed that branched chain amino acids (BCAAs) suppress peripheral blood Kyn transportation to the brain, but plasma BCAA levels were not significantly different between the diet groups in our study. Urine metabolome analysis revealed that feed ingredients affected the excretion of many metabolites, and MF-fed mice had elevated excretion of kynurenic and quinolinic acids, pivotal metabolites in the Kyn pathway. Collectively, the level of critical metabolites in the Kyn pathway in the central and peripheral tissues was strongly affected by feed ingredients. Therefore, feed selection is a critical factor to ensure the reproducibility of experimental data in studies involving rodent models.

【 授权许可】

CC BY|CC BY-NC