Cohort Profile: The Shaanxi Blood Donor Cohort in China

Frontiers in Cardiovascular Medicine

article

Lei Zhang¹  Hengxin Li⁵  Shu Su¹  Erica M. Wood⁶  Ting Ma¹  Yang Sun⁷  Lingxia Guo⁸  Qianke Cheng⁹  Xiaoyun Gu⁹  Wenjie Wu⁹  Liqin Wang¹  Miao Ding²  Leilei Zhang²  Yuan Shen^1,10  Jiangcun Yang¹ 

[1] Department of Transfusion Medicine, Shaanxi Provincial People’s Hospital;China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science Center;Melbourne Sexual Health Centre, Alfred Health;Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University;Blood Quality Management Office, Shaanxi Provincial Blood Center;Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University;Data Center, Shaanxi Provincial People’s Hospital;Planning Development and Information Office, Health Commission of Shaanxi Province;Department of Information Technological, Shaanxi Health Information Center;Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center

关键词: cohort profile;    blood donation;    ICD-10;    health effects;    China;   

DOI  :  10.3389/fcvm.2022.841253

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Purpose The Shaanxi Blood Donor Cohort was set up to investigate the impact of blood donation on the health of donors compared with non-blood donors. The specific aims of the study include (1) identifying the geographical and temporal trends of incidence for diseases in both blood donors and non-blood donors; (2) assessing the impact of environmental exposures, lifestyle, body mass index (BMI) and blood type on disease burdens, stratified between blood donors and non-blood donors; and (3) among blood donors, investigating if regular blood donation has a positive impact on donors’ health profiles, based on a cohort with a mixed retrospective and prospective study design. Participants A total of 3.4 million adults, with an equal number and identical demographic characteristics (year of birth, sex and location of residence) of blood donors and non-blood donors, were enrolled on 2012. The one-to-one matching was conducted through a repeated random selection of individuals without any history of blood donation from the Shaanxi Electronic Health Records. The cohort has been so far followed up to the end of 2018, summing to nearly 24 million years of follow-up. The cohort will be followed up prospectively every 3 years until 2030. Findings to Date Of the 1.7 million blood donors, 418,312 (24.5%) and 332,569 (19.5%) individuals were outpatients and inpatients, accounting for 1,640,483(96.2%) outpatient and 496,061 (29.1%) inpatient visits. Of the same number of non-blood donors, 407,798 (23.9%) and 346,097 (20.3%) individuals were hospital outpatients and inpatients, accounting for 1,655,725 (97.1%) outpatient and 562,337 (33.0%) inpatient visits. The number of outpatient and inpatient visits by non-blood donors was 0.9 and 3.9% higher than those of the blood donors ( p < 0.01). Blood donors demonstrate significantly fewer inpatients visits than non-blood donors for major chronic disease categories ( p < 0.01). Future Plans We are currently exploring the long term benefits of blood donation on major chronic disease categories and multimorbidities in this large population cohort. The study results are adjusted by the “healthy donor effect.” This cohort study will continue until 2030.

【 授权许可】

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