Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)

Nutrients

Janna A. van Diepen¹  Gabriele Gross¹  Maciej Chichlowski²  Clive J. Petry³  Ieuan A. Hughes³  Ken K. Ong³  Philippa M. Prentice³  David B. Dunger³  Laurentya Olga³  Jacques Vervoort⁴  Jos Boekhorst⁵ 

[1] Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6545 CJ Nijmegen, The Netherlands;Department of Medical Affairs, Mead Johnson Nutrition, Evansville, IN 47721, USA;Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK;Laboratory of Biochemistry, Wageningen University, 6708 PB Wageningen, The Netherlands;NIZO Food Research BV, 6718 ZB Ede, The Netherlands;

关键词: infant growth;    breast milk;    early life;    cohort profile;    infant nutrition;    breast milk nutrients;   

DOI  :  10.3390/nu13082879

来源: DOAJ

【 摘 要 】

Growth and nutrition during early life have been strongly linked to future health and metabolic risks. The Cambridge Baby Growth Study (CBGS), a longitudinal birth cohort of 2229 mother–infant pairs, was set up in 2001 to investigate early life determinant factors of infant growth and body composition in the UK setting. To carry out extensive profiling of breastmilk intakes and composition in relation to infancy growth, the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF) was established upon the original CBGS. The strict inclusion criteria were applied, focusing on a normal birth weight vaginally delivered infant cohort born of healthy and non-obese mothers. Crucially, only infants who were exclusively breastfed for the first 6 weeks of life were retained in the analysed study sample. At each visit from birth, 2 weeks, 6 weeks, and then at 3, 6, 12, 24, and 36 months, longitudinal anthropometric measurements and blood spot collections were conducted. Infant body composition was assessed using air displacement plethysmography (ADP) at 6 weeks and 3 months of age. Breast milk was collected for macronutrients and human milk oligosaccharides (HMO) measurements. Breast milk intake volume was also estimated, as well as sterile breastmilk and infant stool collection for microbiome study.

【 授权许可】

Unknown