Bidirectional Relationship Between Cancer and Heart Failure: Insights on Circulating Biomarkers

Frontiers in Cardiovascular Medicine

article

Michela Chianca¹  Giorgia Panichella¹  Iacopo Fabiani²  Alberto Giannoni¹  Serena L'Abbate¹  Alberto Aimo¹  Annamaria Del Franco¹  Giuseppe Vergaro¹  Chrysanthos Grigoratos²  Vincenzo Castiglione³  Carlo Maria Cipolla⁴  Antonella Fedele⁴  Claudio Passino¹  Michele Emdin¹  Daniela Maria Cardinale⁴ 

[1] Institute of Life Sciences;Cardiology Division;Cardiology Division, Pisa University Hospital;Cardioncology Unit, Cardioncology and Second Opinion Division, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico

关键词: cancer;    inflammation;    cardiovascular disease;    cardio-oncology;    circulating biomarkers;    neuro-hormonal activation;   

DOI  :  10.3389/fcvm.2022.936654

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Cancer and heart failure are the two leading causes of death in developed countries. These two apparently distinct clinical entities share similar risk factors, symptoms, and pathophysiological mechanisms (inflammation, metabolic disturbances, neuro-hormonal and immune system activation, and endothelial dysfunction). Beyond the well-known cardiotoxic effects of oncological therapies, cancer and heart failure are thought to be tied by a bidirectional relationship, where one disease favors the other and vice versa. In this context, biomarkers represent a simple, reproducible, sensitive and cost-effective method to explore such relationship. In this review, we recapitulate the evidence on cardiovascular and oncological biomarkers in the field of cardioncology, focusing on their role in treatment-naïve cancer patients. Cardioncological biomarkers are useful tools in risk stratification, early detection of cardiotoxicity, follow-up, and prognostic assessment. Intriguingly, these biomarkers might contribute to better understand the common pathophysiology of cancer and heart failure, thus allowing the implementation of preventive and treatment strategies in cardioncological patients.

【 授权许可】

CC BY