Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease JACC State-of-the-Art Review

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:75

Review

Narayan, Vivek^1,2  Thompson, Elizabeth W.³  Demissei, Biniyam⁴  Ho, Jennifer E.^5,6  Januzzi, James L., Jr.⁷  Ky, Bonnie^2,4,8 

[1] Univ Penn, Dept Med, Perelman Sch Med, Div Hematol Med Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Med, Perelman Sch Med, Div Cardiol, Philadelphia, PA 19104 USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02115 USA

[6] Harvard Med Sch, Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02115 USA

[7] Harvard Med Sch, Massachusetts Gen Hosp, Baim Inst Clin Res, Cardiol Div, Boston, MA 02115 USA

[8] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

关键词: biomarkers;    cancer;    cardio-oncology;    cardiovascular disease;   

DOI  :  10.1016/j.jacc.2020.03.067

来源: Elsevier

【 摘 要 】

Cardiovascular disease (CVD) and cancer are leading causes of morbidity and mortality worldwide. Although conventionally managed as separate disease processes, recent research has lent insight into compelling commonalities between CVD and cancer, including shared mechanisms for disease development and progression. In this review, the authors discuss several pathophysiological processes common to both CVD and cancer, such as inflammation, resistance to cell death, cellular proliferation, neurohormonal stress, angiogenesis, and genomic instability, in an effort to understand common mechanisms of both disease states. In particular, the authors highlight key circulating and genomic biomarkers associated with each of these processes, as well as their associations with risk and prognosis in both cancer and CVD. The purpose of this state-of-the-art review is to further our understanding of the potential mechanisms underlying cancer and CVD by contextualizing pathways and biomarkers common to both diseases. (C) 2020 by the American College of Cardiology Foundation.

【 授权许可】

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