Diverse Epigenetic Regulations of Macrophages in Atherosclerosis

Frontiers in Cardiovascular Medicine

article

Hongmei Yang¹  Yue Sun¹  Qingchao Li¹  Fengyan Jin³  Yun Dai¹ 

[1] Laboratory of Cancer Precision Medicine, The First Hospital of Jilin University;Department of Critical Care Medicine, The First Hospital of Jilin University;Department of Hematology, The First Hospital of Jilin University

关键词: macrophage;    polarization;    epigenetic;    reprogramming;    chronic inflammation;    atherosclerosis;    therapeutic target;   

DOI  :  10.3389/fcvm.2022.868788

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Emerging research on epigenetics has resulted in many novel discoveries in atherosclerosis (AS), an inflammaging-associated disease characterized by chronic inflammation primarily driven by macrophages. The bulk of evidence has demonstrated the central role of epigenetic machinery in macrophage polarization to pro- (M1-like) or anti-inflammatory (M2-like) phenotype. An increasing number of epigenetic alterations and their modifiers involved in reprogramming macrophages by regulating DNA methylation or histone modifications (e.g., methylation, acetylation, and recently lactylation) have been identified. They may act to determine or skew the direction of macrophage polarization in AS lesions, thereby representing a promising target. Here we describe the current understanding of the epigenetic machinery involving macrophage polarization, to shed light on chronic inflammation-driving onset and progression of inflammaging-associated diseases, using AS as a prototypic example, and discuss the challenge for developing effective therapies targeting the epigenetic modifiers against these diseases, particularly highlighting a potential strategy based on epigenetically-governed repolarization from M1-like to M2-like phenotype.

【 授权许可】

CC BY