Clustering of Unhealthy Lifestyle and the Risk of Adverse Events in Patients With Atrial Fibrillation

Frontiers in Cardiovascular Medicine

article

So-Ryoung Lee¹  Eue-Keun Choi¹  Sang-Hyeon Park¹  Seung-Woo Lee³  Kyung-Do Han⁴  Seil Oh¹  Gregory Y. H. Lip² 

[1] Department of Internal Medicine, Seoul National University Hospital;Department of Internal Medicine, Seoul National University College of Medicine;Department of Medical Statistics, College of Medicine, The Catholic University of Korea;Statistics and Actuarial Science, Soongsil University;Liverpool Center for Cardiovascular Science, University of Liverpool and Liverpool Chest and Heart Hospital;Department of Clinical Medicine, Aalborg University

关键词: atrial fibrillation;    lifestyle;    stroke;    myocardial infarction;    heart failure;   

DOI  :  10.3389/fcvm.2022.885016

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Background Little is known regarding the risk of clinical outcomes depending on the clustering of lifestyle behaviors after atrial fibrillation (AF) diagnosis. This study evaluated the association between a cluster of healthy lifestyle behaviors and the risk of adverse outcomes in patients with AF. Methods Using the Korean National Insurance Service database, patients who were newly diagnosed with AF between 2009 and 2016 were included. A healthy lifestyle behavior score (HLS) was calculated by assigning 1 point each for non-current smoking, for non-drinking, and for performing regular exercise from the self-reported questionnaire in health examinations. The primary outcome was defined as major adverse cardiovascular event (MACE), including ischemic stroke, myocardial infarction, and hospitalization for heart failure. Results A total of 208,662 patients were included; 7.1% in HLS 0, 22.7% in HLS 1, 58.6% in HLS 2, and 11.6% in HLS 3 groups. Patients with HLS 1, 2, and 3 were associated with a lower risk of MACE than those with HLS 0 (adjusted hazard ratio [95% confidence interval (CI)]: 0.788 [0.762–0.855], 0.654 [0.604–0.708], and 0.579 [0.527–0.636], respectively). After propensity score weighting, consistent results were observed. The risk reduction of healthy lifestyle combinations was consistently observed in various subgroups, regardless of the CHA 2 DS 2 -VASc score and oral anticoagulant use. Conclusion Increased number of healthy lifestyle behaviors was significantly associated with lower MACE risk in patients with new-onset AF. These findings support the promotion of a healthy lifestyle to reduce the risk of adverse events in patients with AF.

【 授权许可】

CC BY