Lack of Effects of Renin-Angiotensin-Aldosterone System Activity and Beta-Adrenoceptor Pathway Polymorphisms on the Response to Bisoprolol in Hypertension

Frontiers in Cardiovascular Medicine

article

Weiwei Zeng¹  Tanya T. W. Chu²  Chung Shun Ho³  Clara W. S. Lo³  Alan S. L. Chan³  Alice P. S. Kong²  Brian Tomlinson²  Sze Wa Chan⁵ 

[1] Shenzhen Baoan Women’s and Children’s Hospital, Jinan University;Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong;Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong;Faculty of Medicine, Macau University of Science and Technology;School of Health Sciences, Caritas Institute of Higher Education

关键词: β1-adrenoceptor polymorphism;    bisoprolol;    blood pressure;    renin;    aldosterone;    angiotensin II;   

DOI  :  10.3389/fcvm.2022.842875

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Purpose This study examined the effects of plasma renin activity (PRA), angiotensin II (Ang II) and aldosterone (PAC) concentrations as well as common polymorphisms in the β 1 -Adrenoceptor gene ( ADRB1 ) and the G-protein α-Subunit (G αs ) protein gene the G protein α-Subunit 1 gene ( GNAS ) on the blood pressure (BP) and heart rate (HR) response to bisoprolol in Chinese patients with hypertension. Methods Patients with sitting clinic systolic BP (SBP) 140–169 mmHg and/or diastolic BP (DBP) 90–109 mmHg after placebo run-in were treated with open-label bisoprolol 2.5 mg daily for 6 weeks. Patients diagnosed as having primary aldosteronism or renal artery stenosis were excluded. PRA, Ang II and PAC concentrations were measured after the placebo run-in and after 6 weeks of treatment. The Ser49Gly and Arg389Gly polymorphisms in ADRB1 and the c.393C > T polymorphism in GNAS were genotyped by the TaqMan ® assay. Results In 99 patients who completed the study, baseline PAC levels were significantly associated with baseline DBP and plasma potassium on univariate but not on multivariate linear regression analysis. PRA, Ang II, and PAC concentrations at baseline were not associated with changes in BP with bisoprolol treatment, but the values were all significantly reduced (PRA −0.141 ± 0.595 ng/mL/h, Ang II −2.390 ± 5.171 pmol/L and aldosterone −51.86 ± 119.1 pg/mL; all P T polymorphism in GNAS had no significant association with the BP and HR response to bisoprolol in these patients.

【 授权许可】

CC BY