Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults

Frontiers in Cardiovascular Medicine

article

Qiong Ma¹  Ke-Ke Wang¹  Yue Sun¹  Dan Wang¹  Yu Yan¹  Yan Li³  Hao Jia¹  Ze-Jiaxin Niu¹  Xi Zhang¹  Lan Wang⁴  Zi-Yue Man¹  Wei-Hua Gao⁵  Chun-Hua Li⁶  Jie Zhang⁷  Ke Gao¹  Hui-Xian Li³  John Chang⁸  Gary V. Desir⁸  Wan-Hong Lu³  Jian-Jun Mu¹  Yang Wang¹  Chen Chen¹  Gui-Lin Hu¹  Chao Chu¹  Xiao-Yu Zhang^1,10  Ming-Fei Du¹  Ting Zou¹  Qing Zhou^1,11  Yue-Yuan Liao¹ 

[1] Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University;Key Laboratory of Molecular Cardiology of Shaanxi Province;Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University;Department of Cardiology, Xi'an International Medical Center Hospital;Department of Cardiology, Xi'an No.1 Hospital;Department of Ophthalmology, Xi'an People's Hospital;Department of Cardiology, Xi'an People's Hospital;Department of Medicine, Yale University School of Medicine;Department of Medicine, Veterans Administration Healthcare System;Department of Cardiology, Northwest Women's and Children's Hospital of Xi'an Jiaotong University Health Science Center;National Engineering Research Center for Beijing Biochip Technology

关键词: renalase;    hypertension;    gene polymorphism;    blood pressure;    renal puncture biopsy;   

DOI  :  10.3389/fcvm.2022.800427

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Objective Renalase, a novel secretory flavoprotein with amine oxidase activity, is secreted into the blood by the kidneys and is hypothesized to participate in blood pressure (BP) regulation. We investigated the associations of renalase with BP and the risk of hypertension by examining renalase single nucleopeptide polymorphism (SNPs), serum renalase levels, and renal expression of renalase in humans. Methods ① Subjects ( n = 514) from the original Baoji Salt-Sensitive Study cohort were genotyped to investigate the association of renalase SNPs with longitudinal BP changes and the risk of hypertension during 14 years of follow-up. ② Two thousand three hundred and ninety two participants from the Hanzhong Adolescent Hypertension Study cohort were used to examine the association of serum renalase levels with hypertension. Renalase expression in renal biopsy specimens from 193 patients were measured by immunohistochemistry. ③ Renalase expression was compared in hypertensive vs. normotensive patients. Results ① SNP rs7922058 was associated with 14-year change in systolic BP, and rs10887800, rs796945, rs1935582, rs2296545, and rs2576178 were significantly associated with 14-year change in diastolic BP while rs1935582 and rs2576178 were associated with mean arterial pressure change over 14 years. In addition, SNPs rs796945, rs1935582, and rs2576178 were significantly associated with hypertension incidence. Gene-based analysis found that renalase gene was significantly associated with hypertension incidence over 14-year follow-up after adjustment for multiple measurements. ② Hypertensive subjects had higher serum renalase levels than normotensive subjects (27.2 ± 0.4 vs. 25.1 ± 0.2 μg/mL). Serum renalase levels and BPs showed a linear correlation. In addition, serum renalase was significantly associated with the risk of hypertension [ OR = 1.018 (1.006–1.030)]. ③ The expression of renalase in human renal biopsy specimens significantly decreased in hypertensive patients compared to non-hypertensive patients (0.030 ± 0.001 vs. 0.038 ± 0.004). Conclusions These findings indicate that renalase may play an important role in BP progression and development of hypertension.

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