Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults

Frontiers in Cardiovascular Medicine

John Chang²  Gary V. Desir²  Xiao-Yu Zhang³  Lan Wang⁴  Wei-Hua Gao⁵  Jie Zhang⁶  Xi Zhang⁷  Ming-Fei Du⁷  Ting Zou⁷  Ze-Jiaxin Niu⁷  Hao Jia⁷  Gui-Lin Hu⁷  Ke Gao⁷  Dan Wang⁷  Hui-Xian Li⁸  Wan-Hong Lu⁸  Yan Li⁸  Chun-Hua Li⁹  Ke-Ke Wang^1,10  Yue Sun^1,10  Qiong Ma^1,10  Yang Wang^1,10  Yu Yan^1,10  Jian-Jun Mu^1,10  Chao Chu^1,10  Zi-Yue Man^1,10  Chen Chen^1,10  Yue-Yuan Liao^1,10  Qing Zhou^1,11 

[1] 0Department of Medicine, Yale University School of Medicine, New Haven, CT, United States;1Department of Medicine, Veterans Administration Healthcare System, West Haven, CT, United States;Department of Cardiology, Northwest Women's and Children's Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, China;Department of Cardiology, Xi'an International Medical Center Hospital, Xi'an, China;Department of Cardiology, Xi'an No.1 Hospital, Xi'an, China;Department of Cardiology, Xi'an People's Hospital, Xi'an, China;Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;Department of Ophthalmology, Xi'an People's Hospital, Xi'an, China;Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China;National Engineering Research Center for Beijing Biochip Technology, Beijing, China;

关键词: renalase;    hypertension;    gene polymorphism;    blood pressure;    renal puncture biopsy;   

DOI  :  10.3389/fcvm.2022.800427

来源: DOAJ

【 摘 要 】

ObjectiveRenalase, a novel secretory flavoprotein with amine oxidase activity, is secreted into the blood by the kidneys and is hypothesized to participate in blood pressure (BP) regulation. We investigated the associations of renalase with BP and the risk of hypertension by examining renalase single nucleopeptide polymorphism (SNPs), serum renalase levels, and renal expression of renalase in humans.Methods① Subjects (n = 514) from the original Baoji Salt-Sensitive Study cohort were genotyped to investigate the association of renalase SNPs with longitudinal BP changes and the risk of hypertension during 14 years of follow-up. ② Two thousand three hundred and ninety two participants from the Hanzhong Adolescent Hypertension Study cohort were used to examine the association of serum renalase levels with hypertension. Renalase expression in renal biopsy specimens from 193 patients were measured by immunohistochemistry. ③ Renalase expression was compared in hypertensive vs. normotensive patients.Results① SNP rs7922058 was associated with 14-year change in systolic BP, and rs10887800, rs796945, rs1935582, rs2296545, and rs2576178 were significantly associated with 14-year change in diastolic BP while rs1935582 and rs2576178 were associated with mean arterial pressure change over 14 years. In addition, SNPs rs796945, rs1935582, and rs2576178 were significantly associated with hypertension incidence. Gene-based analysis found that renalase gene was significantly associated with hypertension incidence over 14-year follow-up after adjustment for multiple measurements. ② Hypertensive subjects had higher serum renalase levels than normotensive subjects (27.2 ± 0.4 vs. 25.1 ± 0.2 μg/mL). Serum renalase levels and BPs showed a linear correlation. In addition, serum renalase was significantly associated with the risk of hypertension [OR = 1.018 (1.006–1.030)]. ③ The expression of renalase in human renal biopsy specimens significantly decreased in hypertensive patients compared to non-hypertensive patients (0.030 ± 0.001 vs. 0.038 ± 0.004).ConclusionsThese findings indicate that renalase may play an important role in BP progression and development of hypertension.

【 授权许可】

Unknown