ALB-dNLR Score Predicts Mortality in Coronary Artery Disease Patients After Percutaneous Coronary Intervention

Frontiers in Cardiovascular Medicine

article

Wen-Juan Xiu¹  Hai-Tao Yang¹  Ying-Ying Zheng¹  Ting-Ting Wu¹  Xian-Geng Hou¹  Zhi-Hui Jiang¹  Yi Yang¹  Yi-Tong Ma¹  Xiang Xie¹ 

[1] Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University;Key Laboratory of Cardiac Injury and Repair of Henan Province, Department of Cardiology, First Affiliated Hospital of Zhengzhou University

关键词: albumin and the derived neutrophil to lymphocyte ratio score (ALB-dNLR score);    coronary artery disease;    percutaneous coronary intervention;    mortality;    all-cause mortality;    cardiac mortality;    major adverse cardiovascular events;    major adverse cardiovascular and cerebrovascular events;   

DOI  :  10.3389/fcvm.2022.709868

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Background The influence of the albumin/derived neutrophil and lymphocyte ratio (ALB-dNLR) on the outcomes of patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI) is not known. Here, we aimed to determine the association between the ALB-dNLR score and post-PCI CAD patient outcomes. Methods A total of 6,050 patients from the First Affiliated Hospital of Xinjiang Medical University were enrolled between January 2008 and December 2016. These patients were divided into three groups according to their ALB-dNLR scores (0 points, n = 1,121; 1 point, n = 3,119; 2 points, n = 1,810). Mortality after PCI [all-cause (ACM) and cardiac (CM)] was taken as the primary endpoint. The prognostic value of the ALB-dNLR score was determined with the Cox proportional hazard model after adjustment for covariates. Results The ACM and CM rates differed among participants in the three groups ( P = 0.007 and P = 0.034, respectively). Multivariate Cox analysis showed that the ALB-dNLR score independently predicted both ACM [1 point vs. 0 points, HR = 1.249 (95% CI: 0.79–1.774), P = 0.215; 2 points vs. 0 points, HR = 1.777 (95% CI: 1.239–2.549), P = 0.002] and CM [1 point vs. 0 points, HR = 1.294 (95% CI: 0.871–1.922), P = 0.202; 2 points vs. 0 points, HR = 1.782 (95% CI: 1.185–1.782), P = 0.027]. We also found that among male patients in the three groups, both ACM and CM rates differed ( P = 0.006 and P = 0.017, respectively). Multivariate Cox analysis showed that the ALB-dNLR score independently predicted both ACM [1 point vs. 0 points, HR = 1.237 (95% CI: 0.806–0.330), P = 0.330; 2 points vs. 0 points, HR = 1.790 (95% CI: 1.159–2.764), P = 0.009] and CM [1 point vs. 0 points HR = 1.472 (95% CI: 0.892–2.430), P = 0.130; 2 points vs. 0 points, HR = 1.792 (95% CI: 1.182–3.289), P = 0.009]. Conclusion The ALB-dNLR score is a credible predictor for mortality in patients with CAD who have undergone PCI.

【 授权许可】

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