Prevalence and Mortality of Moderate or Severe Mitral Regurgitation Among Patients Undergoing Percutaneous Coronary Intervention With or Without Heart Failure: Results From CIN Study With 28,358 Patients

Frontiers in Cardiovascular Medicine

article

Haozhang Huang¹  Jin Liu¹  Kunming Bao²  Xiaoyu Huang³  Dehua Huang³  Haiyan Wei⁴  Nuerbahaer Remutula⁴  Tilakezi Tuersun⁴  Wenguang Lai¹  Qiang Li¹  Bo Wang¹  Yibo He¹  Heyin Yang⁴  Shiqun Chen¹  Jiyan Chen¹  Kaihong Chen²  Ning Tan¹  Xiaoyan Wang⁶  Liling Chen²  Yong Liu¹ 

[1] Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences;Department of Cardiology, Longyan First Hospital Affiliated With Fujian Medical University;People's Hospital of Yangjiang;Department of Cardiology, First People's Hospital of Kashgar;Guangdong Provincial People's Hospital, School of Medicine, South China University of Technology;The First Affiliated Hospital, Sun Yat-sen University;Department of Nuclear Medicine, The First Affiliated Hospital of Sun Yat-sen University

关键词: moderate or severe mitral regurgitation;    percutaneous coronary intervention;    heart failure;    coronary artery disease;    prevalence;    mortality;   

DOI  :  10.3389/fcvm.2022.796447

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Aim This study investigated the prevalence and mortality associated with moderate or severe mitral regurgitation (MR) among patients undergoing percutaneous coronary intervention (PCI), with or without heart failure (HF). Methods We analyzed patients undergoing PCI without mitral valve surgery from the Cardiorenal ImprovemeNt (CIN) study (ClinicalTrials.gov NCT04407936 ). Patients without echocardiography to determine MR occurrence or lacking follow-up death data were excluded. Primary endpoints were 1-year and long-term all-cause mortality, with a median follow-up time of 5 years (interquartile range: 3.1–7.6). Results Of 28,358 patients undergoing PCI treatment [mean age: 62.7 ± 10.7; women: 6,749 (25.6%)], 3,506 (12.4%) had moderate or severe MR, and there was a higher rate of moderate or severe MR in HF group than non-HF group (28.8 vs. 5.6%, respectively). Regardless of HF conditions, patients with moderate or severe MR were older and had worse cardio-renal function and significantly increased 1-year mortality [adjusted hazard ratio (aHR): 1.82, 95% confidence interval (CI): 1.51–2.2], and long-term mortality [aHR: 1.43, 95% CI: 1.3–1.58]. There was no significant difference between patients with HF and those with non-HF ( P for interaction > 0.05). Conclusion One-eighth of the patients undergoing PCI had moderate or severe MR. Furthermore, one-third and one-seventeenth experienced moderate or severe MR with worse cardiorenal function in the HF and non-HF groups, and increased consistent mortality risk. Further studies should explore the efficacy of mitral interventional procedures for moderate or severe MR after PCI treatment, regardless of HF.

【 授权许可】

CC BY