Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain

Frontiers in Cardiovascular Medicine

article

Ashley S. Manchanda¹  Alan C. Kwan²  Mariko Ishimori⁵  Louise E. J. Thomson⁴  Debiao Li³  Daniel S. Berman¹  C. Noel Bairey Merz¹  Caroline Jefferies⁵  Janet Wei¹ 

[1] Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center;Cedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center;Biomedical Imaging Research Institute, Cedars-Sinai Medical Center;Department of Imaging, Mark Taper Imaging Institute, Cedars-Sinai Medical Center;Division of Rheumatology and Department of Biomedical Sciences, Department of Medicine, Cedars-Sinai Medical Center

关键词: systemic lupus erythematosus;    chest pain;    coronary microvascular dysfunction;    coronary vasospasm;    ischemic heart disease;   

DOI  :  10.3389/fcvm.2022.867155

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Chest pain is a common symptom in patients with systemic lupus erythematosus, an autoimmune disease that is associated with increased cardiovascular morbidity and mortality. While chest pain mechanisms can be multifactorial and often attributed to non-coronary or non-cardiac cardiac etiologies, emerging evidence suggests that ischemia with no obstructive coronary arteries (INOCA) is a prevalent condition in patients with chest pain and no obstructive coronary artery disease. Coronary microvascular dysfunction is reported in approximately half of SLE patients with suspected INOCA. In this mini review, we highlight the cardiovascular risk assessment, mechanisms of INOCA, and diagnostic approach for patients with SLE and suspected CMD.

【 授权许可】

CC BY