Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol

Frontiers in Medicine

article

Dixie Ecklund¹  Carol G. T. Vance²  Dana L. Dailey³  John Burns⁴  Asokumar Buvanendran⁵  Robert J. McCarthy⁵  Joshua Jacobs⁶  Xiaohong Joe Zhou⁷  Richard Wixson⁸  Tessa Balach⁹  Chad M. Brummett^1,10  Daniel Clauw^1,10  Douglas Colquhoun^1,10  Steven E. Harte^1,10  Richard E. Harris^1,10  David A. Williams^1,10  Andrew C. Chang^1,14  Jennifer Waljee^1,15  Kathleen M. Fisch^1,16  Kristen Jepsen^1,17  Louise C. Laurent^1,16  Giovanni Berardi²  Laura Frey-Law²  Kathleen A. Sluka²  Emine O. Bayman¹  Christopher S. Coffey¹  Michael Olivier^1,18  Carl D. Langefeld^1,19  Timothy D. Howard^2,20  Oliver Fiehn^2,21  Jon M. Jacobs^2,22  Panshak Dakup^2,22  Wei-Jun Qian^2,22  Adam C. Swensen^2,22  Anna Lokshin^2,23  Martin Lindquist^2,24  Brian S. Caffo^2,24  Ciprian Crainiceanu^2,24  Scott Zeger^2,24  Ari Kahn^2,25  Tor Wager^2,26  Margaret Taub^2,24  James Ford^2,27  Stephani P. Sutherland^2,24  Laura D. Wandner^2,28 

[1] Department of Biostatistics, College of Public Health, University of Iowa;Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa;Department of Physical Therapy, St. Ambrose University;Department of Psychiatry, Rush University Medical Center;Department of Anesthesiology, Rush University Medical Center;Department of Orthopaedic Surgery, Rush University Medical Center;Departments of Radiology, Neurosurgery, and Bioengineering, University of Illinois College of Medicine at Chicago;NorthShore Orthopaedic and Spine Institute, NorthShore University HealthSystem;Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago;Department of Anesthesiology, University of Michigan;Department of Medicine ,(Rheumatology), University of Michigan;Department of Psychiatry, University of Michigan;Department of Psychology, University of Michigan;Section of Thoracic Surgery, University of Michigan;Section of Plastic and Reconstructive Surgery, University of Michigan;Department of Obstetrics, Gynecology and Reproductive Sciences, University of California;Institute of Genomic Medicine Genomics Center, University of California;Department of Internal Medicine, Wake Forest School of Medicine;Department of Biostatistics and Data Science, Wake Forest School of Medicine;Department of Biochemistry, Wake Forest School of Medicine;West Coast Metabolomics Center, University of California;Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory;Department of Pathology, University of Pittsburgh;Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health;Texas Advanced Computing Center, The University of Texas at Austin;Presidential Cluster in Neuroscience, Department of Psychological and Brain Sciences, Dartmouth College;Geisel School of Medicine at Dartmouth;National Institute of Neurological Disorders and Stroke, The National Institutes of Health

关键词: postsurgical pain;    thoracic surgery;    pain;    biomarker;    risk factors;    protocol;    knee arthroplasty;   

DOI  :  10.3389/fmed.2022.849214

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.

【 授权许可】

CC BY