Artificial Ovary for Young Female Breast Cancer Patients

Frontiers in Medicine

article

Jing Chen¹  Luz Angela Torres-de la Roche²  Ulf D. Kahlert³  Vladimir Isachenko⁴  Hui Huang⁵  Jörg Hennefründ²  Xiaohong Yan¹  Qionghua Chen¹  Wenjie Shi²  Youzhu Li¹ 

[1] Reproductive Medicine Center, The First Affiliated Hospital of Xiamen University;University Hospital for Gynecology, Pius-Hospital, University Medicine Oldenburg;Molecular and Experimental Surgery, University Clinic for General, Visceral and Vascular Surgery, University Medicine Magdeburg and Otto-von Guericke University;Research Group for Reproductive Medicine and IVF Laboratory, Department of Obstetrics and Gynecology, Cologne University;Reproductive Medicine Center, Women and Children's Hospital, Xiamen University

关键词: breast cancer;    artificial ovary;    fertility preservation;    cancer recurrence;    follicle;    stem cell;   

DOI  :  10.3389/fmed.2022.837022

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

In recent decades, there has been increasing attention toward the quality of life of breast cancer (BC) survivors. Meeting the growing expectations of fertility preservation and the generation of biological offspring remains a great challenge for these patients. Conventional strategies for fertility preservation such as oocyte and embryo cryopreservation are not suitable for prepubertal cancer patients or in patients who need immediate cancer therapy. Ovarian tissue cryopreservation (OTC) before anticancer therapy and autotransplantation is an alternative option for these specific indications but has a risk of retransplantation malignant cells. An emerging strategy to resolve these issues is by constructing an artificial ovary combined with stem cells, which can support follicle proliferation and ensure sex hormone secretion. This promising technique can meet both demands of improving the quality of life and meanwhile fulfilling their expectation of biological offspring without the risk of cancer recurrence.

【 授权许可】

CC BY