Application of Animal Models in Interpreting Dry Eye Disease

Frontiers in Medicine

article

Jun Zhu¹  Takenori Inomata¹  Kendrick Co Shih⁵  Yuichi Okumura¹  Kenta Fujio¹  Tianxiang Huang¹  Ken Nagino³  Yasutsugu Akasaki¹  Keiichi Fujimoto¹  Ai Yanagawa³  Maria Miura¹  Akie Midorikawa-Inomata⁴  Kunihiko Hirosawa¹  Mizu Kuwahara¹  Hurramhon Shokirova¹  Atsuko Eguchi⁴  Yuki Morooka¹  Fang Chen²  Akira Murakami¹ 

[1] Department of Ophthalmology, Juntendo University Graduate School of Medicine;Department of Ophthalmology, Northern Jiangsu People's Hospital;Department of Digital Medicine, Juntendo University Graduate School of Medicine;Department of Hospital Administration, Juntendo University Graduate School of Medicine;Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong

关键词: dry eye;    animal model;    lacrimal gland;    tear deficiency;    evaporative;    environmental stress;    translational research;    DED;   

DOI  :  10.3389/fmed.2022.830592

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Different pathophysiologic mechanisms are involved in the initiation, development, and outcome of dry eye disease (DED). Animal models have proven valuable and efficient in establishing ocular surface microenvironments that mimic humans, thus enabling better understanding of the pathogenesis. Several dry eye animal models, including lacrimal secretion insufficiency, evaporation, neuronal dysfunction, and environmental stress models, are related to different etiological factors. Other models may be categorized as having a multifactorial DED. In addition, there are variations in the methodological classification, including surgical lacrimal gland removal, drug-induced models, irradiation impairment, autoimmune antibody-induced models, and transgenic animals. The aforementioned models may manifest varying degrees of severity or specific pathophysiological mechanisms that contribute to the complexity of DED. This review aimed to summarize various dry eye animal models and evaluate their respective characteristics to improve our understanding of the underlying mechanism and identify therapeutic prospects for clinical purposes.

【 授权许可】

CC BY