Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics?

Frontiers in Cell and Developmental Biology

卷:10

Monica Alves¹  Lilian Eslaine Costa Mendes da Silva²  Marina Zilio Fantucci²  Leidiane Adriano²  Eduardo Melani Rocha²  Jacqueline Ferreira Faustino²  Adriana de Andrade Batista Murashima²  Camila Nunes Lemos² 

[1] Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Brazil;

[2] Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil;

关键词: lacrimal gland;    ocular surface;    oxidative stres;    dry eye;    lacrimal functional unit (LFU);   

DOI  :  10.3389/fcell.2022.824726

来源: DOAJ

【 摘 要 】

Oxidative stress (OS) is a major disruption in the physiology of the lacrimal functional unit (LFU). Antioxidant enzymes have dual protective activities: antioxidant and antimicrobial activities. Peroxidases have been indistinctly used as markers of the secretory activity of the LFU and implicated in the pathophysiology, diagnosis and treatment of dry eye disease (DED), even though they comprise a large family of enzymes that includes lactoperoxidase (LPO) and glutathione peroxidase (GPO), among others. Assays to measure and correlate OS with other local LFU phenomena have methodological limitations. Studies implicate molecules and reactions involved in OS as markers of homeostasis, and other studies identify them as part of the physiopathology of diseases. Despite these conflicting concepts and observations, it is clear that OS is influential in the development of DED. Moreover, many antioxidant strategies have been proposed for its treatment, including calorie restriction to nutritional supplementation. This review offers a critical analysis of the biological mechanisms, diagnostic outcomes, drug use, dietary supplements, and life habits that implicate the influence of OS on DED.

【 授权许可】

Unknown