Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients

Frontiers in Medicine

article

Fei Zhou¹  Karl Peltzer³  Vladimir P. Chekhonin²  Shu Li²  Huiyang Li²  Wenjuan Ma¹  Chao Zhang¹  Yao Xu¹  Basel Abdelazeem⁷  Kirellos Said Abbas⁹  Yile Lin²  Haixiao Wu¹ 

[1] Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital;The Sino-Russian Joint Research Center for Bone Metastasis in Malignant Tumor;Department of Psychology, University of the Free State;N. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation;Department of Public Service Management, School of Management, Tianjin University of Traditional Chinese Medicine;Tianjin Medical University General Hospital;McLaren Health Care;Department of Internal Medicine, Michigan State University;Faculty of Medicine, Alexandria University

关键词: bone metastasis;    non-cancer cause;    cardiovascular;    mortality;    Surveillance Epidemiology and End Results (SEER) database;   

DOI  :  10.3389/fmed.2022.899544

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Purpose To investigate the non-cancer causes of death (COD) in cancer patients with synchronous bone metastasis (BM) that is based on the Surveillance, Epidemiology, and End Results (SEER) database. Methods The retrospective cohort study included malignant cancer patients with synchronous BM diagnosed from 2010 to 2018 in the SEER database. The frequencies and proportion of non-cancer COD were calculated and analyzed in different genders, ages, and races subgroups. Results A total of 97,997 patients were deceased and included into the current study and 6,782 patients were died of non-cancer causes with a male predominance ( N = 4,515, 66.6%). Around half of deaths ( N = 3,254, 48.0%) occurred within 6 months after diagnosis while 721 patients were deceased after 3 years. Lung and bronchus cancer, prostate cancer, breast cancer, kidney and renal pelvis cancer, and liver cancer were proved to be the top five cancer types resulting in non-cancer caused death. Cardiovascular and cerebrovascular diseases were the leading non-cancer cause of death ( N = 2,618), followed by COPD and associated conditions ( N = 553) and septicemia, infectious and parasitic diseases ( N = 544). Sub-analyses stratified by gender, age and race were performed and the similar results with slightly difference were observed. Conclusions Cardiovascular and cerebrovascular diseases were the main non-cancer cause of death in cancer patients with synchronous BM. Other non-cancer causes included COPD, septicemia, infectious and parasitic diseases, and so on. These findings should be considered by physicians. Physicians can counsel cancer patients with BM regarding survivorship with death causes screening and focus on prevention of non-cancer deaths.

【 授权许可】

CC BY