Theragnostic 64 Cu/ 67 Cu Radioisotopes Production With RFT-30 Cyclotron

Frontiers in Medicine

article

Jun Young Lee¹  Jung Ho Chae¹  Min Goo Hur¹  Seung Dae Yang¹  Young Bae Kong¹  Jongchul Lee¹  Jin Sik Ju¹  Pyeong Seok Choi¹  Jeong Hoon Park¹ 

[1] Accelerator and Radioisotope Development Team, Korea Atomic Energy Research Institute

关键词: Copper-64;    Copper-67;    cyclotron;    radioisotope;    pair-radioisotope;   

DOI  :  10.3389/fmed.2022.889640

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

64 Cu and 67 Cu are theragnostic pair radionuclides with promising application in the nuclear medicine. 64 Cu is PET nuclide for the non-invasive diagnosis and 67 Cu is beta emitter for therapy of various cancers. This study discusses optimization efforts in the production of these radioactive coppers carried out with 30 MeV cyclotron. Optimized conditions include target preparation, chemical separation, and quality control. The production routes of 64 Cu and 67 Cu were studied based on the nuclear reactions of 64 Ni(p,n) 64 Cu and 70 Zn(p,α) 67 Cu. The produced 64 Cu and 67 Cu have >99.9% of the radionuclidic purity. The yield at the end of bombardment (EOB) of 64 Cu and 67 Cu is 28.5 MBq/μAh and 67 Cu is 0.58 MBq/μAh, respectively.

【 授权许可】

CC BY